Trajectory Aware Macro-cell Planning for Mobile Users

We design and evaluate algorithms for efficient user-mobility driven macro-cell planning in cellular networks. As cellular networks embrace heterogeneous technologies (including long range 3G/4G and short range WiFi, Femto-cells, etc.), most traffic generated by static users gets absorbed by the short-range technologies, thereby increasingly leaving mobile user traffic to macro-cells. To this end, we consider a novel approach that factors in the trajectories of mobile users as well as the impact of city geographies and their associated road networks for macro-cell planning. Given a budget k of base-stations that can be upgraded, our approach selects a deployment that impacts the most number of user trajectories. The generic formulation incorporates the notion of quality of service of a user trajectory as a parameter to allow different application-specific requirements, and operator choices.We show that the proposed trajectory utility maximization problem is NP-hard, and design multiple heuristics. We evaluate our algorithms with real and synthetic data sets emulating different city geographies to demonstrate their efficacy. For instance, with an upgrade budget k of 20%, our algorithms perform 3-8 times better in improving the user quality of service on trajectories in different city geographies when compared to greedy location-based base-station upgrades.Comment: Published in INFOCOM 201

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field

Ranking Issues for Information Integration

Ranking of query/search answers, although introduced by early information retrieval systems, has become mandatory for internet searches. When the answers of a query or search are varying in quality and are large in numbers, it is necessary to rank/order these answers based on some criteria. From a users ’ viewpoint, ranking is extremely useful especially when associated with the retrieval of a few (topk) answers. Currently, the notion of ranking is being applied to database query answers (ordering based on user criteria) in order to retrieve top-k answers. One of the challenges is to push ranking computation into the query processing stage to make it efficient and eliminate post processing operations. In this paper, we argue that top-k answers and ranking will become mandatory as well for searches that involve integration of information from heterogeneous domains. However, it is not clear how ranking can be supported as sources are autonomous and support different characteristics and capabilities. We analyze possible alternatives for supporting ranking while answering queries in this context and propose potential approaches. The discussion is in the context of InfoMosaic, a framework proposed by the authors for information integration.

Spatio-Temporal Signatures of User-Centric Data: How Similar Are We?

Much work has been done on understanding and predicting human mobility in time. In this work, we are interested in obtaining a set of users who are spatio-temporally most similar to a query user. We propose an efficient way of user data representation called Spatio-Temporal Signatures to keep track of complete record of user movement. We define a measure called Spatio-Temporal similarity for comparing a given pair of users. Although computing exact pairwise Spatio-Temporal similarities between query user with all users is inefficient, we show that with our hybrid pruning scheme the most similar users can be obtained in logarithmic time with in a (1+\epsilon) factor approximation of the optimal. We are developing a framework to test our models against a real dataset of urban users